diff --git a/LifeSciences/README.md b/LifeSciences/README.md
index 2fd359dd05ab9f7badc27e23c5994e7fc89541eb..c3d25753b410a735caecaa9b9e911b392edc09f2 100644
--- a/LifeSciences/README.md
+++ b/LifeSciences/README.md
@@ -4,3 +4,4 @@ Life Sciences Software List:
 - repositories: genewise-2.4.1
 - repositories: trimmomatic-0.40
 - repositories: RepeatMasker-4.1.2
+- repositories: rMATs-4.1.2
diff --git a/LifeSciences/rMATs-4.1.2/Makefile-lbfgs_scipy.patch b/LifeSciences/rMATs-4.1.2/Makefile-lbfgs_scipy.patch
new file mode 100644
index 0000000000000000000000000000000000000000..b2fa4acb514a7f4e5d25a7369609fe3fef8ef24f
--- /dev/null
+++ b/LifeSciences/rMATs-4.1.2/Makefile-lbfgs_scipy.patch
@@ -0,0 +1,12 @@
+--- ./rMATS_C/lbfgs_scipy/Makefile      2021-12-17 21:25:43.000000000 +0800
++++ ./rMATS_C/lbfgs_scipy/Makefile1     2022-05-11 10:54:28.247013460 +0800
+@@ -1,7 +1,7 @@
+ # Set compiler if not set by environment variable
+-ifndef FC
+-FC := gfortran
+-endif
++#ifndef FC
++FC := flang
++#endif
+
+ FFLAGS = -c -O2
diff --git a/LifeSciences/rMATs-4.1.2/Makefile.rMATS_C.patch b/LifeSciences/rMATs-4.1.2/Makefile.rMATS_C.patch
new file mode 100644
index 0000000000000000000000000000000000000000..4690e727c04857dc74de11d146e0d60782a4dc47
--- /dev/null
+++ b/LifeSciences/rMATs-4.1.2/Makefile.rMATS_C.patch
@@ -0,0 +1,28 @@
+--- ./rMATS_C/Makefile  2021-12-17 21:25:43.000000000 +0800
++++ ./rMATS_C/Makefile1 2022-05-11 14:42:01.715013460 +0800
+@@ -1,15 +1,15 @@
+ # Set compilers if not set by environment variables
+-ifndef CC
+-CC := gcc
+-endif
+-ifndef CXX
+-CXX := g++
+-endif
+-ifndef FC
+-FC := gfortran
+-endif
++#ifndef CC
++CC := clang
++#endif
++#ifndef CXX
++CXX := clang++
++#endif
++#ifndef FC
++FC := flang
++#endif
+
+-LDFLAGS := -lm -lgfortran -lgsl -lgslcblas -lgomp -lblas -llapack
++LDFLAGS := -lm -lflang -lgsl -lgslcblas -lgomp -lblas -llapack
+ CFLAGS := -Wall -O2 -msse2 -funroll-loops -fopenmp
+
+ # Allow gsl flags to be set by environment variable
diff --git a/LifeSciences/rMATs-4.1.2/build.sh b/LifeSciences/rMATs-4.1.2/build.sh
new file mode 100644
index 0000000000000000000000000000000000000000..181c523d1b9a70138f72e901bf87bd770b0d9aac
--- /dev/null
+++ b/LifeSciences/rMATs-4.1.2/build.sh
@@ -0,0 +1,78 @@
+#!/bin/bash
+if [[ $# -ne 2 ]]; then
+    echo "The format is as follows:"
+    echo "bash build.sh buildpath installpath"
+    echo ":param buildpath: 应用构建绝对路径"
+    echo ":param installpath: 应用安装绝对路径"
+    exit 1
+fi
+
+[[ ! "$1" =~ ^/.* || "$1" = "/" ]] &&  echo "请输入正确的构建路径" && exit 1
+[[ ! "$2" =~ ^/.* || "$2" = "/" ]] &&  echo "请输入正确的安装路径" && exit 1
+
+create_dir()
+{
+    local path=$1
+    [[ "$path" =~ .*/$ ]] && path=${path%/*}
+    if [[ ! -d "$path" && ! -f "$path" ]]; then mkdir -p $path; else path=$path`date "+%y%m%d%H%M%S"` && mkdir -p $path; fi
+    echo $path
+}
+
+buildpath=$(create_dir $1)
+installpath=$(create_dir $2)
+
+yum install -y m4 bc environment-modules systemd-devel --nogpgcheck
+source /etc/profile
+module purge
+
+set -e
+dep_dir="dependency"
+echo 'start install bisheng' >> log.txt
+bash $dep_dir/bisheng-compiler-2.1.0.sh $buildpath $installpath
+module use $installpath/bisheng-compiler-2.1.0
+module load $installpath/bisheng-compiler-2.1.0/bisheng_modulefiles
+echo 'Bisheng installation is complete' >> log.txt
+
+echo 'start install gsl-2.5' >> log.txt
+bash $dep_dir/gsl-2.5.sh $buildpath $installpath
+module use $installpath/gsl-2.5
+module load $installpath/gsl-2.5/gsl_modulefiles
+echo 'Gsl-2.5 installation is complete' >> log.txt
+
+echo 'start install blas' >> log.txt
+bash $dep_dir/blas-3.10.0.sh $buildpath $installpath
+echo 'Blas installation is complete' >> log.txt
+
+echo 'start install lapack' >> log.txt
+bash $dep_dir/lapack-3.10.1.sh $buildpath $installpath
+echo 'Lapack installation is complete' >> log.txt
+
+echo 'start install R' >> log.txt
+bash $dep_dir/R-4.2.0.sh $buildpath $installpath
+module use $installpath/R-4.2.0
+module load $installpath/R-4.2.0/R-4.2.0_modulefiles
+echo 'R installation is complete' >> log.txt
+
+ln -sf $installpath/BLAS-3.10.0/lib/* /usr/lib64
+ln -sf $installpath/lapack-3.10.1/lib/* /usr/lib64
+
+echo 'start install rmats' >> log.txt
+bash rmats-4.1.2.sh $buildpath $installpath
+echo 'Rmats installation is complete' >> log.txt
+
+
+mkdir -p pkg/rmats-4.1.2-hpc && cp -r $installpath/* pkg/rmats-4.1.2-hpc/
+cat>"pkg/rmats-4.1.2-hpc/run.sh"<<EOF
+#!/bin/bash
+yum install -y python2-numpy*
+current_dir=\$(cd "\$(dirname "\${BASH_SOURCE[0]}")" &> /dev/null && pwd)
+for d in \$(ls \$current_dir)
+do
+  [[ ! -f "\$current_dir/\$d" ]] && cd \$current_dir/\$d && module use \$(pwd) && module load \$(pwd)/*modulefiles &> /dev/null
+done
+	
+EOF
+
+cd pkg/ && tar zcvf rmats-4.1.2-hpc.tar.gz rmats-4.1.2-hpc
+
+rm -rf $buildpath $installpath
diff --git a/LifeSciences/rMATs-4.1.2/dependency/R-4.2.0.sh b/LifeSciences/rMATs-4.1.2/dependency/R-4.2.0.sh
new file mode 100644
index 0000000000000000000000000000000000000000..ea5eab87f8282b6c3808958b051bac64c524baf7
--- /dev/null
+++ b/LifeSciences/rMATs-4.1.2/dependency/R-4.2.0.sh
@@ -0,0 +1,54 @@
+#!/bin/bash
+
+if [[ $# -ne 2 ]]; then
+    echo "The format is as follows:"
+    echo "bash R-4.2.0.sh buildpath installpath"
+    echo ":param buildpath: 应用构建绝对路径"
+    echo ":param installpath: 应用安装绝对路径"
+    exit 1
+fi
+
+[[ ! "$1" =~ ^/.* || ! -d "$1" || "$1" = "/" ]] &&  echo "请输入正确的构建路径" && exit 1
+[[ ! "$2" =~ ^/.* || ! -d "$2" || "$2" = "/" ]] &&  echo "请输入正确的安装路径" && exit 1
+
+if [[ "$1" == "$2" ]]; then 
+echo "构建路径与安装路径不能相同，请输入正确的路径"
+exit 1
+fi
+
+buildpath=$1
+installpath=$2
+[[ "$buildpath" =~ .*/$ ]] && buildpath=${buildpath%/*}
+[[ "$installpath" =~ .*/$ ]] && installpath=${installpath%/*}
+set -e
+
+#依赖
+
+yum install wget tar environment-modules readline-devel libXt-devel bzip2-devel xz-devel libcurl-devel glibc-headers gcc-c++ pcre* -y --nogpgcheck
+
+
+
+#R-4.2.0.tar.gz
+wget -t 0 -c -P $buildpath  http://mirror.bjtu.edu.cn/cran/src/base/R-4/R-4.2.0.tar.gz
+tar xf $buildpath/R-4.2.0.tar.gz -C $buildpath && rm -rf $buildpath/R-4.2.0.tar.gz
+cd $buildpath/R-4.2.0
+
+FC=flang CC=clang CXX=clang++ ./configure --enable-R-shlib=yes --with-tcltk --prefix=$installpath/R-4.2.0
+make -j$(nproc) && make install -j$(nproc)
+
+cat>"$installpath/R-4.2.0/R-4.2.0_modulefiles"<<EOF
+#%Module1.0
+conflict R
+variable modfile [file normalize [info script]]
+proc getModulefileDir {} {
+    variable modfile
+    set modfile_path [file dirname \$modfile]
+    return \$modfile_path
+}
+set pwd [getModulefileDir]
+set R \$pwd
+setenv R \$R
+prepend-path PATH \$R/bin
+EOF
+
+rm -rf $buildpath/R-4.2.0
diff --git a/LifeSciences/rMATs-4.1.2/dependency/bisheng-compiler-2.1.0.sh b/LifeSciences/rMATs-4.1.2/dependency/bisheng-compiler-2.1.0.sh
new file mode 100644
index 0000000000000000000000000000000000000000..45f4af1957f987f32206c3082d34f725282206f1
--- /dev/null
+++ b/LifeSciences/rMATs-4.1.2/dependency/bisheng-compiler-2.1.0.sh
@@ -0,0 +1,46 @@
+#!/bin/bash
+
+if [[ $# -ne 2 ]]; then
+    echo "The format is as follows:"
+    echo "bash bisheng-compiler-2.1.0.sh buildpath installpath"
+    echo ":param buildpath: 应用构建绝对路径"
+    echo ":param installpath: 应用安装绝对路径"
+    exit 1
+fi
+
+[[ ! "$1" =~ ^/.* || ! -d "$1" || "$1" = "/" ]] &&  echo "请输入正确的构建路径" && exit 1
+[[ ! "$2" =~ ^/.* || ! -d "$2" || "$2" = "/" ]] &&  echo "请输入正确的安装路径" && exit 1
+
+if [[ "$1" == "$2" ]]; then 
+echo "构建路径与安装路径不能相同，请输入正确的路径"
+exit 1
+fi
+
+buildpath=$1
+installpath=$2
+[[ "$buildpath" =~ .*/$ ]] && buildpath=${buildpath%/*}
+[[ "$installpath" =~ .*/$ ]] && installpath=${installpath%/*}
+set -e
+yum install -y wget tar environment-modules libatomic
+
+wget -t 0 -c -P $buildpath https://mirrors.huaweicloud.com/kunpeng/archive/compiler/bisheng_compiler/bisheng-compiler-2.1.0-aarch64-linux.tar.gz
+tar xf $buildpath/bisheng-compiler-2.1.0-aarch64-linux.tar.gz -C $buildpath && rm -rf $buildpath/bisheng-compiler-2.1.0-aarch64-linux.tar.gz
+mkdir -p $installpath/bisheng-compiler-2.1.0 && cp -r $buildpath/bisheng-compiler-2.1.0-aarch64-linux/* $installpath/bisheng-compiler-2.1.0/
+
+cat>"$installpath/bisheng-compiler-2.1.0/bisheng_modulefiles"<<EOF
+#%Module1.0
+conflict bisheng
+variable modfile [file normalize [info script]]
+proc getModulefileDir {} {
+    variable modfile
+    set modfile_path [file dirname \$modfile]
+    return \$modfile_path
+}
+set pwd [getModulefileDir]
+set BISHENG \$pwd
+setenv BISHENG \$BISHENG
+prepend-path PATH \$BISHENG/bin
+prepend-path LD_LIBRARY_PATH \$BISHENG/lib
+EOF
+
+rm -rf $buildpath/bisheng-compiler-2.1.0-aarch64-linux
diff --git a/LifeSciences/rMATs-4.1.2/dependency/blas-3.10.0.sh b/LifeSciences/rMATs-4.1.2/dependency/blas-3.10.0.sh
new file mode 100644
index 0000000000000000000000000000000000000000..1f8c2fb2d27a3ad3b6fa71c61e3d9b30dffda349
--- /dev/null
+++ b/LifeSciences/rMATs-4.1.2/dependency/blas-3.10.0.sh
@@ -0,0 +1,34 @@
+#!/bin/bash
+
+if [[ $# -ne 2 ]]; then
+    echo "The format is as follows:"
+    echo "bash bals-3.10.0.sh buildpath installpath"
+    echo ":param buildpath: 应用构建绝对路径"
+    echo ":param installpath: 应用安装绝对路径"
+    exit 1
+fi
+
+[[ ! "$1" =~ ^/.* || ! -d "$1" || "$1" = "/" ]] &&  echo "请输入正确的构建路径" && exit 1
+[[ ! "$2" =~ ^/.* || ! -d "$2" || "$2" = "/" ]] &&  echo "请输入正确的安装路径" && exit 1
+
+if [[ "$1" == "$2" ]]; then 
+echo "构建路径与安装路径不能相同，请输入正确的路径"
+exit 1
+fi
+
+buildpath=$1
+installpath=$2
+[[ "$buildpath" =~ .*/$ ]] && buildpath=${buildpath%/*}
+[[ "$installpath" =~ .*/$ ]] && installpath=${installpath%/*}
+set -e
+yum install -y wget tar environment-modules bc --nogpgcheck
+
+wget -t 0 -c -P $buildpath http://www.netlib.org/blas/blas.tgz
+tar xf $buildpath/blas.tgz -C $buildpath && rm -rf $buildpath/blas.tgz
+cd $buildpath/BLAS-3.10.0
+flang -c -O3 *.f
+ar rv libblas.a *.o
+mkdir -p $installpath/BLAS-3.10.0/lib/
+cp libblas.a $installpath/BLAS-3.10.0/lib/
+
+rm -rf $buildpath/BLAS-3.10.0
diff --git a/LifeSciences/rMATs-4.1.2/dependency/gsl-2.5.sh b/LifeSciences/rMATs-4.1.2/dependency/gsl-2.5.sh
new file mode 100644
index 0000000000000000000000000000000000000000..e0f2c07376d0e42f5ea03263dff747364151f81f
--- /dev/null
+++ b/LifeSciences/rMATs-4.1.2/dependency/gsl-2.5.sh
@@ -0,0 +1,51 @@
+#!/bin/bash
+
+if [[ $# -ne 2 ]]; then
+    echo "The format is as follows:"
+    echo "bash gsl-2.5.sh buildpath installpath"
+    echo ":param buildpath: 应用构建绝对路径"
+    echo ":param installpath: 应用安装绝对路径"
+    exit 1
+fi
+
+[[ ! "$1" =~ ^/.* || ! -d "$1" || "$1" = "/" ]] &&  echo "请输入正确的构建路径" && exit 1
+[[ ! "$2" =~ ^/.* || ! -d "$2" || "$2" = "/" ]] &&  echo "请输入正确的安装路径" && exit 1
+
+if [[ "$1" == "$2" ]]; then 
+echo "构建路径与安装路径不能相同，请输入正确的路径"
+exit 1
+fi
+
+buildpath=$1
+installpath=$2
+[[ "$buildpath" =~ .*/$ ]] && buildpath=${buildpath%/*}
+[[ "$installpath" =~ .*/$ ]] && installpath=${installpath%/*}
+set -e
+
+yum install -y wget tar environment-modules --nogpgcheck
+
+wget -t 0 -c -P $buildpath http://mirrors.ustc.edu.cn/gnu/gsl/gsl-2.5.tar.gz
+tar xf $buildpath/gsl-2.5.tar.gz -C $buildpath && rm -rf $buildpath/gsl-2.5.tar.gz
+cd $buildpath/gsl-2.5
+CC=clang ./configure --prefix=$installpath/gsl-2.5
+make -j$(nproc) && make -j$(nproc) install
+cat>"$installpath/gsl-2.5/gsl_modulefiles"<<EOF
+#%Module1.0
+conflict gsl
+variable modfile [file normalize [info script]]
+proc getModulefileDir {} {
+    variable modfile
+    set modfile_path [file dirname \$modfile]
+    return \$modfile_path
+}
+set pwd [getModulefileDir]
+set GSL \$pwd
+setenv GSL \$GSL
+prepend-path PATH \$GSL/bin
+prepend-path LIBRARY_PATH \$GSL/lib
+prepend-path LD_LIBRARY_PATH \$GSL/lib
+prepend-path CPLUS_INCLUDE_PATH \$GSL/include
+prepend-path C_INCLUDE_PATH \$GSL/include
+EOF
+
+rm -rf $buildpath/gsl-2.5
diff --git a/LifeSciences/rMATs-4.1.2/dependency/lapack-3.10.1.sh b/LifeSciences/rMATs-4.1.2/dependency/lapack-3.10.1.sh
new file mode 100644
index 0000000000000000000000000000000000000000..c0a58f5cbf56c49dbe7e140b253ff2284a8d1dfa
--- /dev/null
+++ b/LifeSciences/rMATs-4.1.2/dependency/lapack-3.10.1.sh
@@ -0,0 +1,39 @@
+#!/bin/bash
+
+if [[ $# -ne 2 ]]; then
+    echo "The format is as follows:"
+    echo "bash lapack-3.10.1.sh buildpath installpath"
+    echo ":param buildpath: 应用构建绝对路径"
+    echo ":param installpath: 应用安装绝对路径"
+    exit 1
+fi
+
+[[ ! "$1" =~ ^/.* || ! -d "$1" || "$1" = "/" ]] &&  echo "请输入正确的构建路径" && exit 1
+[[ ! "$2" =~ ^/.* || ! -d "$2" || "$2" = "/" ]] &&  echo "请输入正确的安装路径" && exit 1
+
+if [[ "$1" == "$2" ]]; then 
+echo "构建路径与安装路径不能相同，请输入正确的路径"
+exit 1
+fi
+
+buildpath=$1
+installpath=$2
+[[ "$buildpath" =~ .*/$ ]] && buildpath=${buildpath%/*}
+[[ "$installpath" =~ .*/$ ]] && installpath=${installpath%/*}
+set -e
+yum install -y wget tar environment-modules --nogpgcheck
+
+wget -t 0 -c -P $buildpath http://www.netlib.org/lapack/lapack.tgz
+tar xf $buildpath/lapack.tgz -C $buildpath && rm -rf $buildpath/lapack.tgz
+cp $buildpath/lapack-3.10.1/make.inc.example  $buildpath/lapack-3.10.1/make.inc
+
+sed -i -e 's/gcc/clang/g' \
+       -e 's/gfortran/flang/g' \
+	   -e 's/TIMER = INT_ETIME/#TIMER = INT_ETIME/g' \
+	   -e 's/#TIMER = INT_CPU_TIME/TIMER = INT_CPU_TIME/g' $buildpath/lapack-3.10.1/make.inc
+cd $buildpath/lapack-3.10.1/
+make -j$(nproc) -i
+mkdir -p $installpath/lapack-3.10.1/lib
+cp *.a $installpath/lapack-3.10.1/lib
+
+rm -rf $buildpath/lapack-3.10.1
diff --git "a/LifeSciences/rMATs-4.1.2/doc/rMATs-4.1.2\345\272\224\347\224\250\346\265\213\350\257\225\346\212\245\345\221\212.docx" "b/LifeSciences/rMATs-4.1.2/doc/rMATs-4.1.2\345\272\224\347\224\250\346\265\213\350\257\225\346\212\245\345\221\212.docx"
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Binary files /dev/null and "b/LifeSciences/rMATs-4.1.2/doc/\351\262\262\351\271\217\345\237\272\345\272\247\350\275\257\344\273\266\346\220\255\345\273\272\346\214\207\345\215\227.docx" differ
diff --git a/LifeSciences/rMATs-4.1.2/rmats-4.1.2.sh b/LifeSciences/rMATs-4.1.2/rmats-4.1.2.sh
new file mode 100644
index 0000000000000000000000000000000000000000..038462fd586b15a5072085911e181b49e30e973b
--- /dev/null
+++ b/LifeSciences/rMATs-4.1.2/rmats-4.1.2.sh
@@ -0,0 +1,37 @@
+#!/bin/bash
+
+if [[ $# -ne 2 ]]; then
+    echo "The format is as follows:"
+    echo "bash rmats-4.1.2.sh buildpath installpath"
+    echo ":param buildpath: 应用构建绝对路径"
+    echo ":param installpath: 应用安装绝对路径"
+    exit 1
+fi
+
+[[ ! "$1" =~ ^/.* || ! -d "$1" || "$1" = "/" ]] &&  echo "请输入正确的构建路径" && exit 1
+[[ ! "$2" =~ ^/.* || ! -d "$2" || "$2" = "/" ]] &&  echo "请输入正确的安装路径" && exit 1
+
+if [[ "$1" == "$2" ]]; then 
+echo "构建路径与安装路径不能相同，请输入正确的路径"
+exit 1
+fi
+
+buildpath=$1
+installpath=$2
+[[ "$buildpath" =~ .*/$ ]] && buildpath=${buildpath%/*}
+[[ "$installpath" =~ .*/$ ]] && installpath=${installpath%/*}
+yum install -y wget tar patch Cython cmake git --nogpgcheck
+
+set -e
+wget -t 0 -c https://github.com/Xinglab/rmats-turbo/releases/download/v4.1.2/rmats_turbo_v4_1_2.tar.gz -O $buildpath/rMATS_v4.1.2.tar.gz
+tar xf $buildpath/rMATS_v4.1.2.tar.gz -C $buildpath && rm -rf $buildpath/rMATS_v4.1.2.tar.gz
+cp Makefile.rMATS_C.patch $buildpath/rmats_turbo_v4_1_2/rMATS_C
+cp Makefile-lbfgs_scipy.patch $buildpath/rmats_turbo_v4_1_2/rMATS_C/lbfgs_scipy
+cd $buildpath/rmats_turbo_v4_1_2
+patch -p0 < ./rMATS_C/Makefile.rMATS_C.patch
+patch -p0 < ./rMATS_C/lbfgs_scipy/Makefile-lbfgs_scipy.patch
+./build_rmats --no-paired-model
+
+mkdir -p $installpath/rmats-4.1.2 && cp -r $buildpath/rmats_turbo_v4_1_2/* $installpath/rmats-4.1.2
+
+rm -rf $buildpath/rmats-4.1.2
diff --git a/README.md b/README.md
index 944cbe0fc4c16943d0b48ee82939769317c4b703..59638400ae413d0565c03d853fe15b8d4ffdda89 100644
--- a/README.md
+++ b/README.md
@@ -4,3 +4,4 @@ HPC Software List:
 - repositories: LifeSciences/genewise-2.4.1
 - repositories: LifeSciences/trimmomatic-0.40
 - repositories: LifeSciences/RepeatMasker-4.1.2
+- repositories: LifeSciences/rMATs-4.1.2