diff --git a/LifeSciences/Manta-1.6.0/build.sh b/LifeSciences/Manta-1.6.0/build.sh
new file mode 100644
index 0000000000000000000000000000000000000000..c5493f3349a96625d34a5f453fb987173e4c6643
--- /dev/null
+++ b/LifeSciences/Manta-1.6.0/build.sh
@@ -0,0 +1,52 @@
+#!/bin/bash
+if [[ $# -ne 2 ]]; then
+    echo "The format is as follows:"
+    echo "bash build.sh buildpath installpath"
+    echo ":param buildpath: 应用构建绝对路径"
+    echo ":param installpath: 应用安装绝对路径"
+    exit 1
+fi
+
+[[ ! "$1" =~ ^/.* || "$1" = "/" ]] &&  echo "请输入正确的构建路径" && exit 1
+[[ ! "$2" =~ ^/.* || "$2" = "/" ]] &&  echo "请输入正确的安装路径" && exit 1
+
+create_dir()
+{
+    local path=$1
+    [[ "$path" =~ .*/$ ]] && path=${path%/*}
+    if [[ ! -d "$path" && ! -f "$path" ]]; then mkdir -p $path; else path=$path`date "+%y%m%d%H%M%S"` && mkdir -p $path; fi
+    echo $path
+}
+
+buildpath=$(create_dir $1)
+installpath=$(create_dir $2)
+
+yum install -y m4 environment-modules systemd-devel
+source /etc/profile
+module purge
+
+set -e
+dep_dir="dependency"
+bash $dep_dir/bisheng-compiler-2.1.0.sh $buildpath $installpath
+module use $installpath/bisheng-compiler-2.1.0
+module load $installpath/bisheng-compiler-2.1.0/bisheng_modulefiles
+
+bash manta-1.6.0.sh $buildpath $installpath
+mkdir -p pkg/manta-1.6.0-hpc && cp -r $installpath/* pkg/manta-1.6.0-hpc/
+cat>"pkg/manta-1.6.0-hpc/run.sh"<<EOF
+#!/bin/bash
+yum install -y m4 environment-modules systemd-devel csh time patch libatomic perl-Data-Dumper \\
+autoconf automake libtool numactl binutils valgrind flex wget tar libatomic gcc-c++ git \\
+doxygen tar bzip2 libstdc++-static zlib zlib-devel graphviz cmake
+source /etc/profile &> /dev/null 
+current_dir=\$(cd "\$(dirname "\${BASH_SOURCE[0]}")" &> /dev/null && pwd)
+for d in \$(ls \$current_dir)
+do
+    [[ ! -f "\$current_dir/\$d" ]] && cd \$current_dir/\$d && module use \$(pwd) && module load \$(pwd)/*modulefiles
+done
+
+EOF
+cd pkg/ && tar zcvf manta-1.6.0-hpc.tar.gz manta-1.6.0-hpc
+
+rm -rf $buildpath $installpath
+
diff --git a/LifeSciences/Manta-1.6.0/dependency/bisheng-compiler-2.1.0.sh b/LifeSciences/Manta-1.6.0/dependency/bisheng-compiler-2.1.0.sh
new file mode 100644
index 0000000000000000000000000000000000000000..3be7ce1a7ca5a3468b87fb74e93920979896c997
--- /dev/null
+++ b/LifeSciences/Manta-1.6.0/dependency/bisheng-compiler-2.1.0.sh
@@ -0,0 +1,41 @@
+#!/bin/bash
+
+if [[ $# -ne 2 ]]; then
+    echo "The format is as follows:"
+    echo "bash bisheng-compiler-2.1.0.sh buildpath installpath"
+    echo ":param buildpath: 应用构建绝对路径"
+    echo ":param installpath: 应用安装绝对路径"
+    exit 1
+fi
+
+[[ ! "$1" =~ ^/.* || ! -d "$1" || "$1" = "/" ]] &&  echo "请输入正确的构建路径" && exit 1
+[[ ! "$2" =~ ^/.* || ! -d "$2" || "$2" = "/" ]] &&  echo "请输入正确的安装路径" && exit 1
+
+buildpath=$1
+installpath=$2
+[[ "$buildpath" =~ .*/$ ]] && buildpath=${buildpath%/*}
+[[ "$installpath" =~ .*/$ ]] && installpath=${installpath%/*}
+set -e
+yum install -y wget tar environment-modules libatomic
+
+wget -t 0 -c -P $buildpath https://mirrors.huaweicloud.com/kunpeng/archive/compiler/bisheng_compiler/bisheng-compiler-2.1.0-aarch64-linux.tar.gz
+tar xf $buildpath/bisheng-compiler-2.1.0-aarch64-linux.tar.gz -C $buildpath && rm -rf $buildpath/bisheng-compiler-2.1.0-aarch64-linux.tar.gz
+mkdir -p $installpath/bisheng-compiler-2.1.0 && cp -r $buildpath/bisheng-compiler-2.1.0-aarch64-linux/* $installpath/bisheng-compiler-2.1.0/
+
+cat>"$installpath/bisheng-compiler-2.1.0/bisheng_modulefiles"<<EOF
+#%Module1.0
+conflict bisheng
+variable modfile [file normalize [info script]]
+proc getModulefileDir {} {
+    variable modfile
+    set modfile_path [file dirname \$modfile]
+    return \$modfile_path
+}
+set pwd [getModulefileDir]
+set BISHENG \$pwd
+setenv BISHENG \$BISHENG
+prepend-path PATH \$BISHENG/bin
+prepend-path LD_LIBRARY_PATH \$BISHENG/lib
+EOF
+
+rm -rf $buildpath/bisheng-compiler-2.1.0-aarch64-linux
diff --git "a/LifeSciences/Manta-1.6.0/doc/Manta-1.6.0\345\272\224\347\224\250\346\265\213\350\257\225\346\212\245\345\221\212.docx" "b/LifeSciences/Manta-1.6.0/doc/Manta-1.6.0\345\272\224\347\224\250\346\265\213\350\257\225\346\212\245\345\221\212.docx"
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Binary files /dev/null and "b/LifeSciences/Manta-1.6.0/doc/Manta-1.6.0\345\272\224\347\224\250\346\265\213\350\257\225\346\212\245\345\221\212.docx" differ
diff --git "a/LifeSciences/Manta-1.6.0/doc/Manta-1.6.0\345\272\224\347\224\250\347\247\273\346\244\215\346\214\207\345\215\227.docx" "b/LifeSciences/Manta-1.6.0/doc/Manta-1.6.0\345\272\224\347\224\250\347\247\273\346\244\215\346\214\207\345\215\227.docx"
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diff --git "a/LifeSciences/Manta-1.6.0/doc/\351\262\262\351\271\217\345\237\272\345\272\247\350\275\257\344\273\266\346\220\255\345\273\272\346\214\207\345\215\227.docx" "b/LifeSciences/Manta-1.6.0/doc/\351\262\262\351\271\217\345\237\272\345\272\247\350\275\257\344\273\266\346\220\255\345\273\272\346\214\207\345\215\227.docx"
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Binary files /dev/null and "b/LifeSciences/Manta-1.6.0/doc/\351\262\262\351\271\217\345\237\272\345\272\247\350\275\257\344\273\266\346\220\255\345\273\272\346\214\207\345\215\227.docx" differ
diff --git a/LifeSciences/Manta-1.6.0/manta-1.6.0.sh b/LifeSciences/Manta-1.6.0/manta-1.6.0.sh
new file mode 100644
index 0000000000000000000000000000000000000000..15f4d347296e8ed5806acb81c989444511bf349e
--- /dev/null
+++ b/LifeSciences/Manta-1.6.0/manta-1.6.0.sh
@@ -0,0 +1,48 @@
+#!/bin/bash
+
+if [[ $# -ne 2 ]]; then
+    echo "The format is as follows:"
+    echo "bash manta-1.6.0.sh buildpath installpath"
+    echo ":param buildpath: 应用构建绝对路径"
+    echo ":param installpath: 应用安装绝对路径"
+    exit 1
+fi
+
+[[ ! "$1" =~ ^/.* || ! -d "$1" || "$1" = "/" ]] &&  echo "请输入正确的构建路径" && exit 1
+[[ ! "$2" =~ ^/.* || ! -d "$2" || "$2" = "/" ]] &&  echo "请输入正确的安装路径" && exit 1
+
+buildpath=$1
+installpath=$2
+[[ "$buildpath" =~ .*/$ ]] && buildpath=${buildpath%/*}
+[[ "$installpath" =~ .*/$ ]] && installpath=${installpath%/*}
+[[ "$buildpath" == "$installpath" ]] && echo "构建路径与安装路径需为不同路径" && exit 1
+yum install -y  environment-modules csh time patch libatomic perl-Data-Dumper autoconf automake libtool numactl binutils systemd-devel valgrind flex wget
+
+set -e
+yum install -y doxygen tar bzip2 libstdc++-static zlib zlib-devel graphviz cmake 
+
+wget -t 0 -c -P $buildpath https://github.com/Illumina/manta/archive/refs/tags/v1.6.0.tar.gz 
+tar -zxvf $buildpath/v1.6.0.tar.gz -C $buildpath && rm -rf $buildpath/v1.6.0.tar.gz
+cd $buildpath/manta-1.6.0
+mkdir build && cd build
+CC=clang CXX=clang++ ../configure --jobs=$(nproc) --prefix=$installpath/manta-1.6.0
+make -j$(nproc) install
+
+cat>"$installpath/manta-1.6.0/manta_modulefiles"<<EOF
+#%Module1.0
+conflict manta
+variable modfile [file normalize [info script]]
+proc getModulefileDir {} {
+    variable modfile
+    set modfile_path [file dirname \$modfile]
+    return \$modfile_path
+}
+set pwd [getModulefileDir]
+set MANTA \$pwd
+setenv MANTA \$MANTA
+prepend-path PATH \$MANTA/bin
+EOF
+
+rm -rf $buildpath/manta-1.6.0
+
+
diff --git a/LifeSciences/README.md b/LifeSciences/README.md
index 646c6c67d545506d98b928206738d45d406b8d4b..756b703357ca6cb1e7705f4da8ac227fda9ac8d9 100644
--- a/LifeSciences/README.md
+++ b/LifeSciences/README.md
@@ -5,4 +5,5 @@ Life Sciences Software List:
 - repositories: trimmomatic-0.40
 - repositories: RepeatMasker-4.1.2
 - repositories: eigensoft-7.2.1
-- repositories: redundans-v0.13c
\ No newline at end of file
+- repositories: redundans-v0.13c
+- repositories: Manta-1.6.0
\ No newline at end of file
diff --git a/README.md b/README.md
index 830f6915806cb05824abf16a6db97ef1b4f9bacf..5d2acc911cdd91f16659ae235d9e466a76b21b2a 100644
--- a/README.md
+++ b/README.md
@@ -5,4 +5,5 @@ HPC Software List:
 - repositories: LifeSciences/trimmomatic-0.40
 - repositories: LifeSciences/RepeatMasker-4.1.2
 - repositories: LifeSciences/eigensoft-7.2.1
-- repositories: LifeSciences/redundans-v0.13c
\ No newline at end of file
+- repositories: LifeSciences/redundans-v0.13c
+- repositories: LifeSciences/Manta-1.6.0
\ No newline at end of file