diff --git a/LifeSciences/README.md b/LifeSciences/README.md
index 367845be4aa4e9181ab63cd49a1aa6d9bf688499..125a1338214bb1cea805525f1a79834e5a7b6338 100644
--- a/LifeSciences/README.md
+++ b/LifeSciences/README.md
@@ -1,3 +1,4 @@
 Life Sciences Software List:
 - repositories: xxx
 - repositories: TRF-4.09.1
+- repositories: genewise-2.4.1
diff --git a/LifeSciences/genewise-2.4.1/build.sh b/LifeSciences/genewise-2.4.1/build.sh
new file mode 100644
index 0000000000000000000000000000000000000000..12974a65fabf82d139f7fafbbbf309c1ce6795b8
--- /dev/null
+++ b/LifeSciences/genewise-2.4.1/build.sh
@@ -0,0 +1,49 @@
+#!/bin/bash
+if [[ $# -ne 2 ]]; then
+    echo "The format is as follows:"
+    echo "bash build.sh buildpath installpath"
+    echo ":param buildpath: 应用构建绝对路径"
+    echo ":param installpath: 应用安装绝对路径"
+    exit 1
+fi
+
+[[ ! "$1" =~ ^/.* || "$1" = "/" ]] &&  echo "请输入正确的构建路径" && exit 1
+[[ ! "$2" =~ ^/.* || "$2" = "/" ]] &&  echo "请输入正确的安装路径" && exit 1
+
+create_dir()
+{
+    local path=$1
+    [[ "$path" =~ .*/$ ]] && path=${path%/*}
+    if [[ ! -d "$path" && ! -f "$path" ]]; then mkdir -p $path; else path=$path`date "+%y%m%d%H%M%S"` && mkdir -p $path; fi
+    echo $path
+}
+
+buildpath=$(create_dir $1)
+installpath=$(create_dir $2)
+
+yum install -y environment-modules
+source /etc/profile
+module purge
+
+set -e
+dep_dir="dependency"
+bash $dep_dir/bisheng-compiler-2.1.0.sh $buildpath $installpath
+module use $installpath/bisheng-compiler-2.1.0
+module load $installpath/bisheng-compiler-2.1.0/bisheng_modulefiles
+
+bash genewise-2.4.1.sh $buildpath $installpath
+mkdir -p pkg/genewise-2.4.1-hpc && cp -r $installpath/* pkg/genewise-2.4.1-hpc/
+cat>"pkg/genewise-2.4.1-hpc/run.sh"<<EOF
+#!/bin/bash
+yum install -y environment-modules systemd-devel csh time patch libatomic
+source /etc/profile &> /dev/null 
+current_dir=\$(cd "\$(dirname "\${BASH_SOURCE[0]}")" &> /dev/null && pwd)
+for d in \$(ls \$current_dir)
+do
+    [[ ! -f "\$current_dir/\$d" ]] && cd \$current_dir/\$d && module use \$(pwd) && module load \$(pwd)/*modulefiles
+done
+EOF
+cd pkg/ && tar zcvf genewise-2.4.1-hpc.tar.gz genewise-2.4.1-hpc
+
+rm -rf $buildpath $installpath
+
diff --git a/LifeSciences/genewise-2.4.1/dependency/bisheng-compiler-2.1.0.sh b/LifeSciences/genewise-2.4.1/dependency/bisheng-compiler-2.1.0.sh
new file mode 100644
index 0000000000000000000000000000000000000000..a53069995751e081370ff3e2559fbc3b2dfd3f4c
--- /dev/null
+++ b/LifeSciences/genewise-2.4.1/dependency/bisheng-compiler-2.1.0.sh
@@ -0,0 +1,43 @@
+#!/bin/bash
+
+if [[ $# -ne 2 ]]; then
+    echo "The format is as follows:"
+    echo "bash bisheng-compiler-2.1.0.sh buildpath installpath"
+    echo ":param buildpath: 应用构建绝对路径"
+    echo ":param installpath: 应用安装绝对路径"
+    exit 1
+fi
+
+[[ ! "$1" =~ ^/.* || ! -d "$1" || "$1" = "/" ]] &&  echo "请输入正确的构建路径" && exit 1
+[[ ! "$2" =~ ^/.* || ! -d "$2" || "$2" = "/" ]] &&  echo "请输入正确的安装路径" && exit 1
+
+buildpath=$1
+installpath=$2
+[[ "$buildpath" =~ .*/$ ]] && buildpath=${buildpath%/*}
+[[ "$installpath" =~ .*/$ ]] && installpath=${installpath%/*}
+[[ "$buildpath" == "$installpath" ]] && echo "构建路径与安装路径需为不同路径" && exit 1
+set -e
+yum install -y wget tar environment-modules libatomic
+
+wget -t 0 -c -P $buildpath https://mirrors.huaweicloud.com/kunpeng/archive/compiler/bisheng_compiler/bisheng-compiler-2.1.0-aarch64-linux.tar.gz
+tar xf $buildpath/bisheng-compiler-2.1.0-aarch64-linux.tar.gz -C $buildpath && rm -rf $buildpath/bisheng-compiler-2.1.0-aarch64-linux.tar.gz
+mkdir -p $installpath/bisheng-compiler-2.1.0 && cp -r $buildpath/bisheng-compiler-2.1.0-aarch64-linux/* $installpath/bisheng-compiler-2.1.0/
+
+cat>"$installpath/bisheng-compiler-2.1.0/bisheng_modulefiles"<<EOF
+#%Module1.0
+conflict bisheng
+variable modfile [file normalize [info script]]
+proc getModulefileDir {} {
+    variable modfile
+    set modfile_path [file dirname \$modfile]
+    return \$modfile_path
+}
+set pwd [getModulefileDir]
+set BISHENG \$pwd
+setenv BISHENG \$BISHENG
+prepend-path PATH \$BISHENG/bin
+prepend-path LD_LIBRARY_PATH \$BISHENG/lib
+EOF
+
+rm -rf $buildpath/bisheng-compiler-2.1.0-aarch64-linux
+
diff --git "a/LifeSciences/genewise-2.4.1/doc/Genewise-2.4.1\345\272\224\347\224\250\346\265\213\350\257\225\346\212\245\345\221\212.docx" "b/LifeSciences/genewise-2.4.1/doc/Genewise-2.4.1\345\272\224\347\224\250\346\265\213\350\257\225\346\212\245\345\221\212.docx"
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Binary files /dev/null and "b/LifeSciences/genewise-2.4.1/doc/Genewise-2.4.1\345\272\224\347\224\250\346\265\213\350\257\225\346\212\245\345\221\212.docx" differ
diff --git "a/LifeSciences/genewise-2.4.1/doc/Genewise-2.4.1\345\272\224\347\224\250\347\247\273\346\244\215\346\214\207\345\215\227.docx" "b/LifeSciences/genewise-2.4.1/doc/Genewise-2.4.1\345\272\224\347\224\250\347\247\273\346\244\215\346\214\207\345\215\227.docx"
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Binary files /dev/null and "b/LifeSciences/genewise-2.4.1/doc/Genewise-2.4.1\345\272\224\347\224\250\347\247\273\346\244\215\346\214\207\345\215\227.docx" differ
diff --git "a/LifeSciences/genewise-2.4.1/doc/\351\262\262\351\271\217\345\237\272\345\272\247\350\275\257\344\273\266\346\220\255\345\273\272\346\214\207\345\215\227.docx" "b/LifeSciences/genewise-2.4.1/doc/\351\262\262\351\271\217\345\237\272\345\272\247\350\275\257\344\273\266\346\220\255\345\273\272\346\214\207\345\215\227.docx"
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Binary files /dev/null and "b/LifeSciences/genewise-2.4.1/doc/\351\262\262\351\271\217\345\237\272\345\272\247\350\275\257\344\273\266\346\220\255\345\273\272\346\214\207\345\215\227.docx" differ
diff --git a/LifeSciences/genewise-2.4.1/genewise-2.4.1.sh b/LifeSciences/genewise-2.4.1/genewise-2.4.1.sh
new file mode 100644
index 0000000000000000000000000000000000000000..db6cf47f3c7a05de485396ca058d1c854800b2c8
--- /dev/null
+++ b/LifeSciences/genewise-2.4.1/genewise-2.4.1.sh
@@ -0,0 +1,51 @@
+#!/bin/bash
+
+if [[ $# -ne 2 ]]; then
+    echo "The format is as follows:"
+    echo "bash genewise-2.4.1.sh buildpath installpath"
+    echo ":param buildpath: 应用构建绝对路径"
+    echo ":param installpath: 应用安装绝对路径"
+    exit 1
+fi
+
+[[ ! "$1" =~ ^/.* || ! -d "$1" || "$1" = "/" ]] &&  echo "请输入正确的构建路径" && exit 1
+[[ ! "$2" =~ ^/.* || ! -d "$2" || "$2" = "/" ]] &&  echo "请输入正确的安装路径" && exit 1
+
+buildpath=$1
+installpath=$2
+[[ "$buildpath" =~ .*/$ ]] && buildpath=${buildpath%/*}
+[[ "$installpath" =~ .*/$ ]] && installpath=${installpath%/*}
+[[ "$buildpath" == "$installpath" ]] && echo "构建路径与安装路径需为不同路径" && exit 1
+yum install -y  environment-modules libatomic wget glib2 glib2-devel
+
+set -e
+wget -t 0 -c -P $buildpath https://www.ebi.ac.uk/~birney/wise2/wise2.4.1.tar.gz 
+tar xf $buildpath/wise2.4.1.tar.gz -C $buildpath && rm -rf $buildpath/wise2.4.1.tar.gz
+cd $buildpath/wise2.4.1/src
+find . -name  makefile | xargs sed -i 's/glib-config/pkg-config glib-2.0/'
+sed -i 's/getline/getline_ReadSeqVars/g' ./HMMer2/sqio.c
+sed -i 's/isnumber/isdigit/' models/phasemodel.c
+sed -i -e 's/csh welcome.csh/sh welcome.csh/' \
+       -e '25s/cc/clang/' \
+       -e '40s/$/-fsigned-char -march=armv8.2-a/' makefile
+sed -i 's/-ldyna_glib/-ldyna_glib `pkg-config --libs glib-2.0`/' models/makefile
+make all | tee make.log
+mkdir -p $installpath/wise2.4.1 && cp -r $buildpath/wise2.4.1/* $installpath/wise2.4.1
+
+rm -rf $buildpath/wise2.4.1
+cat>"$installpath/wise2.4.1/genewise_modulefiles"<<EOF
+#%Module1.0
+conflict genewise
+variable modfile [file normalize [info script]]
+proc getModulefileDir {} {
+    variable modfile
+        set modfile_path [file dirname \$modfile]
+	    return \$modfile_path
+    }
+set pwd [getModulefileDir]
+set GENEWISE \$pwd
+setenv GENEWISE \$GENEWISE
+prepend-path PATH \$GENEWISE/src/bin
+prepend-path WISECONFIGDIR \$GENEWISE/wisecfg
+EOF
+
diff --git a/README.md b/README.md
index ca3b545a4351604a64ad3548fb7518996dffa439..c86d8b9a1927878a6b74911afbcbaa2bbebd9a93 100644
--- a/README.md
+++ b/README.md
@@ -1,3 +1,4 @@
 HPC Software List:
 - repositories: MeteorologicalOcean/wrf-4.2
 - repositories: LifeSciences/TRF-4.09.1
+- repositories: LifeSciences/genewise-2.4.1