diff --git a/LifeSciences/README.md b/LifeSciences/README.md
index 6c9d77d3dc76df3bd39a0fba37fc25eea28ca522..12c6acc102bd2e9f19b0b7005a8ca9b5ffbcc12e 100644
--- a/LifeSciences/README.md
+++ b/LifeSciences/README.md
@@ -8,4 +8,5 @@ Life Sciences Software List:
 - repositories: redundans-v0.13c
 - repositories: bamtools-2.5.2
 - repositories: flye-2.9
-- repositories: Manta-1.6.0
\ No newline at end of file
+- repositories: Manta-1.6.0
+- repositories: hmmer-3.3.2
diff --git a/LifeSciences/hmmer-3.3.2/build.sh b/LifeSciences/hmmer-3.3.2/build.sh
new file mode 100644
index 0000000000000000000000000000000000000000..b2460218c7698f7adfc892bdf062d70d7ae41ca2
--- /dev/null
+++ b/LifeSciences/hmmer-3.3.2/build.sh
@@ -0,0 +1,60 @@
+#!/bin/bash
+export LANG="en_US.UTF-8"
+if [[ $# -ne 2 ]]; then
+    echo "The format is as follows:"
+    echo "bash build.sh buildpath installpath"
+    echo ":param buildpath: 应用构建绝对路径"
+    echo ":param installpath: 应用安装绝对路径"
+    exit 1
+fi
+
+[[ ! "$1" =~ ^/.* || "$1" = "/" ]] &&  echo "请输入正确的构建路径" && exit 1
+[[ ! "$2" =~ ^/.* || "$2" = "/" ]] &&  echo "请输入正确的安装路径" && exit 1
+
+create_dir()
+{
+    local path=$1
+    [[ "$path" =~ .*/$ ]] && path=${path%/*}
+    if [[ ! -d "$path" && ! -f "$path" ]]; then mkdir -p $path; else path=$path`date "+%y%m%d%H%M%S"` && mkdir -p $path; fi
+    echo $path
+}
+
+buildpath=$(create_dir $1)
+installpath=$(create_dir $2)
+[[ "$buildpath" == "$installpath" ]] && echo "构建路径与安装路径需为不同路径" && exit 1
+yum install -y m4 environment-modules systemd-devel
+source /etc/profile
+module purge
+
+set -e
+dep_dir="dependency"
+bash $dep_dir/bisheng-compiler-2.1.0.sh $buildpath $installpath
+module use $installpath/bisheng-compiler-2.1.0
+module load $installpath/bisheng-compiler-2.1.0/bisheng_modulefiles
+
+bash $dep_dir/hmpi-1.1.1.sh $buildpath $installpath
+module use $installpath/hmpi-1.1.1
+module load $installpath/hmpi-1.1.1/hmpi_modulefiles
+
+bash $dep_dir/autoconf-2.71.sh $buildpath $installpath
+module use $installpath/autoconf-2.71
+module load $installpath/autoconf-2.71/autoconf_modulefiles
+
+bash hmmer-3.3.2.sh $buildpath $installpath
+
+mkdir -p pkg/hmmer-3.3.2-hpc && cp -r $installpath/* pkg/hmmer-3.3.2-hpc/
+cat>"pkg/hmmer-3.3.2-hpc/run.sh"<<EOF
+#!/bin/bash
+yum install -y m4 environment-modules systemd-devel csh time patch libatomic perl-Data-Dumper \\
+autoconf automake libtool numactl binutils valgrind flex wget tar libatomic gcc-c++ git
+source /etc/profile &> /dev/null
+current_dir=\$(cd "\$(dirname "\${BASH_SOURCE[0]}")" &> /dev/null && pwd)
+for d in \$(ls \$current_dir)
+do
+    [[ ! -f "\$current_dir/\$d" ]] && cd \$current_dir/\$d && module use \$(pwd) && module load \$(pwd)/*modulefiles
+done
+cd \$current_dir/
+export PATH=\$current_dir/hmmer-3.3.2/bin:\$PATH
+EOF
+rm -rf $buildpath $installpath
+cd pkg/ && tar zcvf hmmer-3.3.2-hpc.tar.gz hmmer-3.3.2-hpc
diff --git a/LifeSciences/hmmer-3.3.2/dependency/autoconf-2.71.sh b/LifeSciences/hmmer-3.3.2/dependency/autoconf-2.71.sh
new file mode 100644
index 0000000000000000000000000000000000000000..5ba4981ec5abff8dca2e43e26f0e36f217bb53de
--- /dev/null
+++ b/LifeSciences/hmmer-3.3.2/dependency/autoconf-2.71.sh
@@ -0,0 +1,46 @@
+#!/bin/bash
+
+if [[ $# -ne 2 ]]; then
+    echo "The format is as follows:"
+    echo "bash autoconf-2.71.sh buildpath installpath"
+    echo ":param buildpath: 应用构建绝对路径"
+    echo ":param installpath: 应用安装绝对路径"
+    exit 1
+fi
+
+[[ ! "$1" =~ ^/.* || ! -d "$1" || "$1" = "/" ]] &&  echo "请输入正确的构建路径" && exit 1
+[[ ! "$2" =~ ^/.* || ! -d "$2" || "$2" = "/" ]] &&  echo "请输入正确的安装路径" && exit 1
+
+buildpath=$1
+installpath=$2
+[[ "$buildpath" =~ .*/$ ]] && buildpath=${buildpath%/*}
+[[ "$installpath" =~ .*/$ ]] && installpath=${installpath%/*}
+[[ "$buildpath" == "$installpath" ]] && echo "构建路径与安装路径需为不同路径" && exit 1
+set -e
+yum install -y wget tar environment-modules
+
+wget -t 10 -c -P $buildpath http://ftp.gnu.org/gnu/autoconf/autoconf-2.71.tar.gz
+cd $buildpath
+tar -zxvf autoconf-2.71.tar.gz
+cd autoconf-2.71
+./configure --prefix=$installpath/autoconf-2.71
+make && make install
+
+mkdir -p $installpath/autoconf-2.71 && cp -r $buildpath/autoconf-2.71/* $installpath/autoconf-2.71/
+
+cat>"$installpath/autoconf-2.71/autoconf_modulefiles"<<EOF
+#%Module1.0
+conflict autoconf
+variable modfile [file normalize [info script]]
+proc getModulefileDir {} {
+    variable modfile
+    set modfile_path [file dirname \$modfile]
+    return \$modfile_path
+}
+set pwd [getModulefileDir]
+set AUTOCONF \$pwd
+setenv AUTOCONF \$AUTOCONF
+prepend-path PATH \$AUTOCONF/bin
+EOF
+
+rm -rf $buildpath/autoconf-2.71
diff --git a/LifeSciences/hmmer-3.3.2/dependency/bisheng-compiler-2.1.0.sh b/LifeSciences/hmmer-3.3.2/dependency/bisheng-compiler-2.1.0.sh
new file mode 100644
index 0000000000000000000000000000000000000000..341edaf5816fff2a502d25c33eaedc7178ae8201
--- /dev/null
+++ b/LifeSciences/hmmer-3.3.2/dependency/bisheng-compiler-2.1.0.sh
@@ -0,0 +1,42 @@
+#!/bin/bash
+export LANG="en_US.UTF-8"
+if [[ $# -ne 2 ]]; then
+    echo "The format is as follows:"
+    echo "bash bisheng-compiler-2.1.0.sh buildpath installpath"
+    echo ":param buildpath: 应用构建绝对路径"
+    echo ":param installpath: 应用安装绝对路径"
+    exit 1
+fi
+
+[[ ! "$1" =~ ^/.* || ! -d "$1" || "$1" = "/" ]] &&  echo "请输入正确的构建路径" && exit 1
+[[ ! "$2" =~ ^/.* || ! -d "$2" || "$2" = "/" ]] &&  echo "请输入正确的安装路径" && exit 1
+
+buildpath=$1
+installpath=$2
+[[ "$buildpath" =~ .*/$ ]] && buildpath=${buildpath%/*}
+[[ "$installpath" =~ .*/$ ]] && installpath=${installpath%/*}
+[[ "$buildpath" == "$installpath" ]] && echo "构建路径与安装路径需为不同路径" && exit 1
+set -e
+yum install -y wget tar environment-modules libatomic
+
+wget -t 10 -c -P $buildpath https://mirrors.huaweicloud.com/kunpeng/archive/compiler/bisheng_compiler/bisheng-compiler-2.1.0-aarch64-linux.tar.gz
+tar xf $buildpath/bisheng-compiler-2.1.0-aarch64-linux.tar.gz -C $buildpath && rm -rf $buildpath/bisheng-compiler-2.1.0-aarch64-linux.tar.gz
+mkdir -p $installpath/bisheng-compiler-2.1.0 && cp -r $buildpath/bisheng-compiler-2.1.0-aarch64-linux/* $installpath/bisheng-compiler-2.1.0/
+
+cat>"$installpath/bisheng-compiler-2.1.0/bisheng_modulefiles"<<EOF
+#%Module1.0
+conflict bisheng
+variable modfile [file normalize [info script]]
+proc getModulefileDir {} {
+    variable modfile
+    set modfile_path [file dirname \$modfile]
+    return \$modfile_path
+}
+set pwd [getModulefileDir]
+set BISHENG \$pwd
+setenv BISHENG \$BISHENG
+prepend-path PATH \$BISHENG/bin
+prepend-path LD_LIBRARY_PATH \$BISHENG/lib
+EOF
+
+rm -rf $buildpath/bisheng-compiler-2.1.0-aarch64-linux
diff --git a/LifeSciences/hmmer-3.3.2/dependency/hmpi-1.1.1.sh b/LifeSciences/hmmer-3.3.2/dependency/hmpi-1.1.1.sh
new file mode 100644
index 0000000000000000000000000000000000000000..1c40ecb7605127094602cc4fc016d79958c3de78
--- /dev/null
+++ b/LifeSciences/hmmer-3.3.2/dependency/hmpi-1.1.1.sh
@@ -0,0 +1,71 @@
+#!/bin/bash
+export LANG="en_US.UTF-8"
+if [[ $# -ne 2 ]]; then
+    echo "The format is as follows:"
+    echo "bash hmpi-1.1.1.sh buildpath installpath"
+    echo ":param buildpath: 应用构建绝对路径"
+    echo ":param installpath: 应用安装绝对路径"
+    exit 1
+fi
+
+[[ ! "$1" =~ ^/.* || ! -d "$1" || "$1" = "/" ]] &&  echo "请输入正确的构建路径" && exit 1
+[[ ! "$2" =~ ^/.* || ! -d "$2" || "$2" = "/" ]] &&  echo "请输入正确的安装路径" && exit 1
+
+buildpath=$1
+installpath=$2
+[[ "$buildpath" =~ .*/$ ]] && buildpath=${buildpath%/*}
+[[ "$installpath" =~ .*/$ ]] && installpath=${installpath%/*}
+[[ "$buildpath" == "$installpath" ]] && echo "构建路径与安装路径需为不同路径" && exit 1
+set -e
+yum install -y wget tar perl-Data-Dumper autoconf automake libtool numactl binutils systemd-devel valgrind flex environment-modules gcc-c++ git
+
+download_pkg()
+{
+    wget -t 10 -c -P $buildpath $1
+    tar xf $buildpath/v1.1.1-huawei.tar.gz -C $buildpath
+    rm -rf $buildpath/v1.1.1-huawei.tar.gz
+}
+
+download_pkg https://github.com/kunpengcompute/hmpi/archive/refs/tags/v1.1.1-huawei.tar.gz
+download_pkg https://github.com/kunpengcompute/hucx/archive/refs/tags/v1.1.1-huawei.tar.gz
+download_pkg https://github.com/kunpengcompute/xucg/archive/refs/tags/v1.1.1-huawei.tar.gz
+cp -r $buildpath/xucg-1.1.1-huawei/* $buildpath/hucx-1.1.1-huawei/src/ucg/
+cd $buildpath/hucx-1.1.1-huawei
+git init && ./autogen.sh
+./contrib/configure-opt --prefix=$installpath/hmpi-1.1.1/hucx-1.1.1-huawei --disable-numa CC=clang CXX=clang++ FC=flang
+for file in `find . -name Makefile`;do sed -i "s/-Werror//g" $file;done
+for file in `find . -name Makefile`;do sed -i "s/-implicit-function-declaration//g" $file;done
+make -j$(nproc)
+make -j$(nproc) install
+export PATH=$installpath/hmpi-1.1.1/hucx-1.1.1-huawei/bin:$PATH
+export LD_LIBRARY_PATH=$installpath/hmpi-1.1.1/hucx-1.1.1-huawei/lib:$LD_LIBRARY_PATH
+export INCLUDE=$installpath/hmpi-1.1.1/hucx-1.1.1-huawei/include:$INCLUDE
+cd $buildpath/hmpi-1.1.1-huawei
+./autogen.pl CC=clang CXX=clang++ FC=flang
+./configure --prefix=$installpath/hmpi-1.1.1/hmpi-1.1.1-huawei --with-platform=contrib/platform/mellanox/optimized --enable-mpil-compatibility \
+	--with-ucx=$installpath/hmpi-1.1.1/hucx-1.1.1-huawei CC=clang CXX=clang++ FC=flang
+make -j$(nproc)
+make -j$(nproc) install
+cat>"$installpath/hmpi-1.1.1/hmpi_modulefiles"<<EOF
+#%Module1.0
+conflict hmpi
+variable modfile [file normalize [info script]]
+proc getModulefileDir {} {
+    variable modfile
+    set modfile_path [file dirname \$modfile]
+    return \$modfile_path
+}
+set pwd [getModulefileDir]
+set HUCX \$pwd/hucx-1.1.1-huawei
+setenv HUCX \$HUCX
+prepend-path PATH \$HUCX/bin
+prepend-path LD_LIBRARY_PATH \$HUCX/lib
+prepend-path INCLUDE \$HUCX/include
+set HMPI \$pwd/hmpi-1.1.1-huawei
+setenv HMPI \$HMPI
+prepend-path PATH \$HMPI/bin
+prepend-path LD_LIBRARY_PATH \$HMPI/lib
+prepend-path INCLUDE \$HMPI/include
+EOF
+
+rm -rf $buildpath/xucg-1.1.1-huawei $buildpath/hucx-1.1.1-huawei $buildpath/hmpi-1.1.1-huawei
diff --git "a/LifeSciences/hmmer-3.3.2/doc/HMMER-3.3.2\345\272\224\347\224\250\346\265\213\350\257\225\346\212\245\345\221\212.docx" "b/LifeSciences/hmmer-3.3.2/doc/HMMER-3.3.2\345\272\224\347\224\250\346\265\213\350\257\225\346\212\245\345\221\212.docx"
new file mode 100644
index 0000000000000000000000000000000000000000..bfd93cf1021daf3efe18203752a6c1926f7dd7c2
Binary files /dev/null and "b/LifeSciences/hmmer-3.3.2/doc/HMMER-3.3.2\345\272\224\347\224\250\346\265\213\350\257\225\346\212\245\345\221\212.docx" differ
diff --git "a/LifeSciences/hmmer-3.3.2/doc/HMMER-3.3.2\345\272\224\347\224\250\347\247\273\346\244\215\346\214\207\345\215\227.docx" "b/LifeSciences/hmmer-3.3.2/doc/HMMER-3.3.2\345\272\224\347\224\250\347\247\273\346\244\215\346\214\207\345\215\227.docx"
new file mode 100644
index 0000000000000000000000000000000000000000..c7fe9edd31ec0097718764d410856da8efe24a22
Binary files /dev/null and "b/LifeSciences/hmmer-3.3.2/doc/HMMER-3.3.2\345\272\224\347\224\250\347\247\273\346\244\215\346\214\207\345\215\227.docx" differ
diff --git "a/LifeSciences/hmmer-3.3.2/doc/\351\262\262\351\271\217\345\237\272\345\272\247\350\275\257\344\273\266\346\220\255\345\273\272\346\214\207\345\215\227.docx" "b/LifeSciences/hmmer-3.3.2/doc/\351\262\262\351\271\217\345\237\272\345\272\247\350\275\257\344\273\266\346\220\255\345\273\272\346\214\207\345\215\227.docx"
new file mode 100644
index 0000000000000000000000000000000000000000..397a46d6ba915dacf0fdaad32393f41b26867ff7
Binary files /dev/null and "b/LifeSciences/hmmer-3.3.2/doc/\351\262\262\351\271\217\345\237\272\345\272\247\350\275\257\344\273\266\346\220\255\345\273\272\346\214\207\345\215\227.docx" differ
diff --git a/LifeSciences/hmmer-3.3.2/hmmer-3.3.2.sh b/LifeSciences/hmmer-3.3.2/hmmer-3.3.2.sh
new file mode 100644
index 0000000000000000000000000000000000000000..c3beff692acadf029d0ee71aa3fe9da11a54f87d
--- /dev/null
+++ b/LifeSciences/hmmer-3.3.2/hmmer-3.3.2.sh
@@ -0,0 +1,73 @@
+#!/bin/bash
+export LANG="en_US.UTF-8"
+if [[ $# -ne 2 ]]; then
+    echo "The format is as follows:"
+    echo "bash hmmer-3.3.2.sh buildpath installpath"
+    echo ":param buildpath: 应用构建绝对路径"
+    echo ":param installpath: 应用安装绝对路径"
+    exit 1
+fi
+
+[[ ! "$1" =~ ^/.* || ! -d "$1" || "$1" = "/" ]] &&  echo "请输入正确的构建路径" && exit 1
+[[ ! "$2" =~ ^/.* || ! -d "$2" || "$2" = "/" ]] &&  echo "请输入正确的安装路径" && exit 1
+
+buildpath=$1
+installpath=$2
+[[ "$buildpath" =~ .*/$ ]] && buildpath=${buildpath%/*}
+[[ "$installpath" =~ .*/$ ]] && installpath=${installpath%/*}
+[[ "$buildpath" == "$installpath" ]] && echo "构建路径与安装路径需为不同路径" && exit 1
+yum install -y  environment-modules csh time patch libatomic perl-Data-Dumper autoconf automake libtool numactl binutils systemd-devel valgrind flex wget
+
+set -e
+wget -t 10 -c -P $buildpath https://github.com/EddyRivasLab/hmmer/archive/refs/heads/h3-arm.zip
+unzip $buildpath/h3-arm.zip -d $buildpath
+cd $buildpath/hmmer-h3-arm/
+wget -t 10 -c https://github.com/EddyRivasLab/easel/archive/refs/heads/master.zip
+unzip master.zip
+mv easel-master/ easel/
+autoconf
+export MPICC=mpicc
+export MPICXX=mpicxx
+export MPIFC=mpifort
+
+./configure --prefix=$installpath/hmmer-3.3.2 --enable-mpi --enable-neon CC=$MPICC CXX=$MPICXX FC=$MPIFC F77=$MPIFC
+sed -i 's/esl_FCompare/esl_FCompareNew/g' src/p7_domain.c
+sed -i 's/esl_DCompare/esl_DCompareNew/g' src/p7_domain.c
+sed -i 's/esl_FCompare/esl_FCompareNew/g' src/p7_hit.c
+sed -i 's/esl_DCompare/esl_DCompareNew/g' src/p7_hit.c
+
+sed -i 's/esl_FCompare_old/esl_FCompare/g' src/p7_hmm.c
+sed -i 's/esl_FCompare_old/esl_FCompare/g' src/p7_trace.c
+sed -i 's/esl_FCompare_old/esl_FCompare/g' src/impl_neon/p7_oprofile.c
+sed -i 's/esl_FCompare_old/esl_FCompare/g' src/generic_vtrace.c
+sed -i 's/esl_FCompare_old/esl_FCompare/g' src/p7_bg.c
+sed -i 's/esl_FCompare_old/esl_FCompare/g' src/p7_gmx.c
+
+sed -i '41 d' src/impl_neon/impl_neon.h
+sed -i '29c static inline float' src/impl_neon/impl_neon.h
+sed -i 's/esl_FCompare_old/esl_FCompare/g' src/./generic_stotrace.c
+sed -i 's/esl_FCompare_old/esl_FCompare/g' src/./generic_viterbi.c
+sed -i 's/esl_FCompare_old/esl_FCompare/g' src/./modelconfig.c
+sed -i 's/esl_FCompare_old/esl_FCompare/g' src/impl_neon/./stotrace.c
+sed -i 's/esl_FCompare_old/esl_FCompare/g' src/impl_neon/./optacc.c
+make -j$(nproc)
+make check
+make -j$(nproc) install
+
+mkdir -p $installpath/hmmer-3.3.2 && cp -r $buildpath/hmmer-h3-arm/* $installpath/hmmer-3.3.2
+
+rm -rf $buildpath/hmmer-3.3.2
+cat>"$installpath/hmmer-3.3.2/hmmer_modulefiles"<<EOF
+#%Module1.0
+conflict hmmer
+variable modfile [file normalize [info script]]
+proc getModulefileDir {} {
+    variable modfile
+        set modfile_path [file dirname \$modfile]
+	    return \$modfile_path
+    }
+set pwd [getModulefileDir]
+set HMMER \$pwd
+setenv HMMER \$HMMER
+prepend-path PATH \$HMMER/bin
+EOF
diff --git a/README.md b/README.md
index 18e9e15c1e9932a643fb0c84a2fc2aeb310d2a5e..ee3dadbdcae80e21090c00e7f1bd7956e5b8a85a 100644
--- a/README.md
+++ b/README.md
@@ -9,4 +9,5 @@ HPC Software List:
 - repositories: LifeSciences/bamtools-2.5.2
 - repositories: LifeSciences/flye-2.9
 - repositories: LifeSciences/Manta-1.6.0
-- repositories: ManufacturingSimulation/OpenLB-1.5-0
\ No newline at end of file
+- repositories: ManufacturingSimulation/OpenLB-1.5-0
+- repositories: LifeSciences/hmmer-3.3.2