diff --git a/runtime/ic/ic_runtime_stub-inl.h b/runtime/ic/ic_runtime_stub-inl.h
index 38c294ed2b47f6840759e5a22831a9d8481ce511..cfcc9b114cccaae9cf6c0874dcfffca1757b5f24 100644
--- a/runtime/ic/ic_runtime_stub-inl.h
+++ b/runtime/ic/ic_runtime_stub-inl.h
@@ -142,7 +142,10 @@ JSTaggedValue ICRuntimeStub::LoadICByName(JSThread *thread, JSTaggedValue receiv
             }
             if (LIKELY(hclass_value.GetTaggedObject() == hclass)) {
                 JSTaggedValue handler = profile_type_info->Get(index + 1);
-                if (handler.IsUndefined()) {
+                if (UNLIKELY(handler.IsUndefined())) {
+                    // handler is collected by GC.
+                    // Clear profile data to fill it again in LoadMiss.
+                    profile_type_info->Set(thread, index, JSTaggedValue::Undefined());
                     break;
                 }
                 return LoadICWithHandler(thread, receiver, receiver, handler);
@@ -176,7 +179,14 @@ JSTaggedValue ICRuntimeStub::LoadICByValue(JSThread *thread, JSTaggedValue recei
             JSTaggedValue hclass_value = profile_type_info->Get(slot_id + 1);
             if (hclass_value.GetTaggedObject() == hclass) {
                 JSTaggedValue handler = profile_type_info->Get(slot_id + 2);
-                return LoadICWithHandler(thread, receiver, receiver, handler);
+                if (UNLIKELY(handler.IsUndefined())) {
+                    // handler is collected by GC.
+                    // Clear profile data to fill it again in LoadMiss.
+                    profile_type_info->Set(thread, slot_id, JSTaggedValue::Undefined());
+                    profile_type_info->Set(thread, slot_id + 1, JSTaggedValue::Undefined());
+                } else {
+                    return LoadICWithHandler(thread, receiver, receiver, handler);
+                }
             }
         }
     }
@@ -206,7 +216,14 @@ JSTaggedValue ICRuntimeStub::StoreICByValue(JSThread *thread, JSTaggedValue rece
             JSTaggedValue hclass_value = profile_type_info->Get(slot_id + 1);
             if (hclass_value.GetTaggedObject() == hclass) {
                 JSTaggedValue handler = profile_type_info->Get(slot_id + 2);
-                return StoreICWithHandler(thread, receiver, receiver, value, handler);
+                if (UNLIKELY(handler.IsUndefined())) {
+                    // handler is collected by GC.
+                    // Clear profile data to fill it again in StoreMiss.
+                    profile_type_info->Set(thread, slot_id, JSTaggedValue::Undefined());
+                    profile_type_info->Set(thread, slot_id + 1, JSTaggedValue::Undefined());
+                } else {
+                    return StoreICWithHandler(thread, receiver, receiver, value, handler);
+                }
             }
         }
     }
@@ -234,7 +251,10 @@ JSTaggedValue ICRuntimeStub::StoreICByName(JSThread *thread, JSTaggedValue recei
             }
             if (LIKELY(hclass_value.GetTaggedObject() == hclass)) {
                 JSTaggedValue handler = profile_type_info->Get(index + 1);
-                if (handler.IsUndefined()) {
+                if (UNLIKELY(handler.IsUndefined())) {
+                    // handler is collected by GC.
+                    // Clear profile data to fill it again in StoreMiss.
+                    profile_type_info->Set(thread, index, JSTaggedValue::Undefined());
                     break;
                 }
                 return StoreICWithHandler(thread, receiver, receiver, value, handler);
diff --git a/runtime/ic/profile_type_info.cpp b/runtime/ic/profile_type_info.cpp
index e62d72fb6a06cd9a47489d4898a19700e3b45546..08a6e05848eb75317865d33018e16fdaaffc7fff 100644
--- a/runtime/ic/profile_type_info.cpp
+++ b/runtime/ic/profile_type_info.cpp
@@ -70,7 +70,7 @@ void ProfileTypeAccessor::AddHandlerWithKey(JSHandle<JSTaggedValue> key, JSHandl
         return;
     }
     auto profileData = profile_type_info_->Get(slot_id_);
-    if (profileData.IsUndefined() && profile_type_info_->Get(slot_id_ + 1).IsUndefined()) {
+    if (profileData.IsUndefined() || profile_type_info_->Get(slot_id_ + 1).IsUndefined()) {
         profile_type_info_->Set(thread_, slot_id_, key.GetTaggedValue());
         profile_type_info_->Set(thread_, slot_id_ + 1U, dynclass.GetTaggedValue());
         profile_type_info_->Set(thread_, slot_id_ + 2U, handler.GetTaggedValue());