diff --git a/download b/download
index c1f1be796a3887dba500516eb61c895e3c16ace2..3f2dd1d3927b0c509ace0164946c7410073529bf 100644
--- a/download
+++ b/download
@@ -1,2 +1,2 @@
-346b6592ae8f3e2ad13947f80da812b5  webkitgtk-2.50.0.tar.xz
-d77ef7775afd8fca02135d4a89d6b294  webkitgtk-2.50.0.tar.xz.asc
+f68fa552fd47bbce084baf80f4c8a872  webkitgtk-2.50.1.tar.xz
+80a7707aac873857b1e76aeac99f2cee  webkitgtk-2.50.1.tar.xz.asc
diff --git a/i686-build.patch b/i686-build.patch
deleted file mode 100644
index 13f98bc84ceea3795b2d707c4cbbcf889621c8d0..0000000000000000000000000000000000000000
--- a/i686-build.patch
+++ /dev/null
@@ -1,18 +0,0 @@
-diff --git a/Source/JavaScriptCore/llint/LowLevelInterpreter.asm b/Source/JavaScriptCore/llint/LowLevelInterpreter.asm
-index af53fe269664..237fd6aab9c8 100644
---- a/Source/JavaScriptCore/llint/LowLevelInterpreter.asm
-+++ b/Source/JavaScriptCore/llint/LowLevelInterpreter.asm
-@@ -2958,6 +2958,13 @@ _wasm_ipint_call_return_location_wide16:
- _wasm_ipint_call_return_location_wide32:
-     crash()
- 
-+if C_LOOP and not JSVALUE64
-+_op_instanceof_return_location:
-+_op_instanceof_return_location_wide16:
-+_op_instanceof_return_location_wide32:
-+    crash()
-+end
-+
- end # WEBASSEMBLY
- 
- include? LowLevelInterpreterAdditions
diff --git a/s390x-build.patch b/s390x-build.patch
deleted file mode 100644
index 7e1ea01f852d095575b1c0c541dec82762bb2686..0000000000000000000000000000000000000000
--- a/s390x-build.patch
+++ /dev/null
@@ -1,10 +0,0 @@
---- webkitgtk.orig/Source/WebCore/style/StyleBuilderState.cpp
-+++ webkitgtk/Source/WebCore/style/StyleBuilderState.cpp
-@@ -58,6 +58,7 @@
- #include "Settings.h"
- #include "StyleAppleColorFilterProperty.h"
- #include "StyleBuilder.h"
-+#include "StyleBuilderStateInlines.h"
- #include "StyleCachedImage.h"
- #include "StyleCanvasImage.h"
- #include "StyleColor.h"
diff --git a/webkit2gtk3.spec b/webkit2gtk3.spec
index 61eeec65d5ab8b051dfa28157e12e290a876080e..e5ee242ae6a99168bde998ce6f30f86d4b18fba1 100644
--- a/webkit2gtk3.spec
+++ b/webkit2gtk3.spec
@@ -7,7 +7,7 @@
         cp -p %1 _license_files/$(echo '%1' | sed -e 's!/!.!g')
 
 Name:           webkit2gtk3
-Version:        2.50.0
+Version:        2.50.1
 Release:        1%{anolis_release}%{?dist}
 Summary:        GTK Web content engine library
 
@@ -48,11 +48,7 @@ Patch304:       icu60.patch
 ## Upstream patches to remove, hopefully after next update
 ##
 
-# https://bugs.webkit.org/show_bug.cgi?id=299018
-Patch400:       i686-build.patch
-
-# https://bugs.webkit.org/show_bug.cgi?id=298308
-Patch401:       s390x-build.patch
+# No patches currently! :)
 
 Patch1000:      1000-webkitgtk-2.40.5-sw.patch
 BuildRequires:  bison
@@ -320,10 +316,13 @@ export NINJA_STATUS="[%f/%t][%e] "
 %{_datadir}/gir-1.0/JavaScriptCore-4.0.gir
 
 %changelog
-* Tue Oct 14 2025 Bo Ren <rb01097748@alibaba-inc.com> 2.50.0-1.0.1
+* Thu Oct 16 2025 Bo Ren <rb01097748@alibaba-inc.com> 2.50.1-1.0.1
 - Exclude loongarch64
 - cherry-pick `add sw arch #ef8be098b07c4d8a9f809d32a607700f4a420676`. (nijie@wxiat.com)
 
+* Mon Oct 13 2025 Michael Catanzaro <mcatanzaro@redhat.com> - 2.50.1-1
+- Update to 2.50.1
+
 * Tue Oct 07 2025 Michael Catanzaro <mcatanzaro@redhat.com> - 2.50.0-1
 - Update to 2.50.0