diff --git a/htslib-1.19.1.tar.bz2 b/htslib-1.21.tar.bz2
similarity index 39%
rename from htslib-1.19.1.tar.bz2
rename to htslib-1.21.tar.bz2
index da0787c4ddfe0508b2e1b5132be3f09e75414666..7e75bc4d74548acc5b698a1a8150268737cf55c2 100644
Binary files a/htslib-1.19.1.tar.bz2 and b/htslib-1.21.tar.bz2 differ
diff --git a/htslib.spec b/htslib.spec
index 733955a38c4ab353533778103418b05c2bdaafe4..05dea7ed41c72c81a553625dfe408afbf0d23030 100644
--- a/htslib.spec
+++ b/htslib.spec
@@ -1,5 +1,5 @@
 Name:    htslib
-Version: 1.19.1
+Version: 1.21
 Release: 1
 Summary: C library for high-throughput sequencing data formats
 License: MIT and BSD
@@ -83,6 +83,9 @@ rm -rf %{buildroot}/%{_libdir}/libhts.a
 %{_mandir}/man1/tabix.1*
 
 %changelog
+* Fri Nov 22 2024 wangxiaomeng <wangxiaomeng@kylinos.cn> - 1.21-1
+- Update to 1.21
+
 * Sat Mar 23 2024 guoyizhang <kuoi@bioarchlinux.org> - 1.19.1-1
 - Update to 1.19.1